Renal Handling of Bovine I125-superoxide Dismutase in the Avian Kidney

Action of Bovine Superoxide Dismutase

On the Stability of Bovine Superoxide Dismutase

1. Apo-superoxide dismutase was more labile toward a variety of inactivating stresses than was the holoenzyme. 2. cu++ restored catalytic activity to the apoenzyme and markedly enhanced its thermal stability but Cu++ plus Zn++ were needed to attain the stability of the native enzyme. 3. Co’-+ or Hgii were able to replace Zn++ in increasing the thermal stability of the Cu+f-repleted apoenzyme. I...

Superoxide dismutase Superoxide dismutase

Dysregulation of superoxide dismutase in chronic kidney disease.

found in interstitial fl uid, plasma, lymph and synovial fl uid. Few studies have looked at SOD activity and its expression in CKD patients; the present study by Akiyama et al. [8] published in this issue of Nephron Clinical Practice is one of them. The authors found a signifi cant increase in SOD activity in leucocytes in CKD patients, but this increase affects only Cu/Zn-SOD. Moreover, Cu/ZnS...

Electron paramagnetic resonance studies of cobalt-copper bovine superoxide dismutase.

1. EPR spectra of cobalt-copper bovine superoxide dismutase at liquid nitrogen and liquid helium temperature show that the two metal centers are magnetically coupled. The temperature dependence of the spectra indicates that this coupling arises from an exchange interaction. 2. The EPR spectrum of the Co(I1) of the enzyme can only be seen after reduction of the Cu(II), at very low temperature. I...